The venue for the World Summit on Arts and Culture is the Mediterranean Conference Centre, the flagship of all conference facilities in Malta. It consists of 10 halls with a total floor space area of 7,000 square metres.

Previously known as the Sacra Infermeria, or the ‘Holy Infirmary’, for more than two centuries the building was used by the Order of the Knights of Malta as a hospital. After the end of World War 1, the building was turned into Police Headquarters and during World War II the Mediterranean Conference Centre received four direct hits.

In 1978 the building was transformed into a state of the art conference centre with impressive spaces such as the main auditorium, the Republic Hall, and the La Valette Hall, a banqueting venue.